TIP30和VEGF-C在小细胞肺癌中的表达及临床意义

目的 分析TIP30和血管内皮生长因子-C(VEGF-C)在局限期小细胞肺癌(SCLC)中的表达和临床意义。方法 免疫组化法检测68例SCLC原发灶中TIP30和VEGF-C的表达。结果 68例SCLC组织中TIP30和VEGF-C阳性表达率分别为51.5%(35/68)、54.4%(37/68)。VEGF-C表达与淋巴结转移和肿瘤大小相关(P＜0.05),与患者的年龄、性别和吸烟之间差异无统计学意义(P＞0.05)。TIP30表达与患者的年龄、性别、吸烟、淋巴结转移和肿瘤大小之间的差异无统计学意义(P＞0.05)。VEGF-C与TIP30表达呈负相关。TIP30表达阳性SCLC患者的DFS和OS较长。相反,VEGF-C表达阳性SCLC患者的DFS和OS较短。Cox多因素分析提示TIP30和VEGF-C表达是SCLC独立不良预后因素(P＜0.01)。结论 VEGF-C表达与淋巴结转移相关,TIP30阴性和VEGF-C阳性表达的SCLC患者预后差。

The clinic significance of TIP30 and VEGF-C protein expressions in small cell lung cancer

Objective To investigate the correlation between TIP30 and VEGF-C expression and clinicophathological characteristics in resected small cell lung cancer(SCLC)patients and to identify patients with increased risk of cancer recurrence and to provide a theoretical basis for the further clinical prevention of SCLC.Methods Sixty eight resected SCLC patients were included in this study.Paraffin-embedded specimens of patients were used for the evaluation of TIP30 and VEGF-C expression by immunohistochemistry.Results The expression of VEGF-C had positive correlation with lymph node metastasis.TIP30 expression was positively correlated with VEGF-C expression.Patients with low TIP30 expression had shorter Overall survival(OS)and Disease-Free survival(DFS)than those with high TIP30 expression.OS and DFS of the patients with VEGF-C-positive tumors were significantly lower than that of the patients with VEGF-C negative tumors.The multivariate Cox regression analysis showed that low TIP30 and high VEGF-C expression were independent markers of poor OS(P＜0.01)in operable SCLC patients.Conclusion The expression of VEGF-C shows positive correlation with lymph node metastasis.Low TIP30 and high VEGF-C expression are independent prognostic markers of poor overall survival in resected SCLC patients.