糖尿病及糖调节受损患者口腔念珠菌感染率及阳性率影响因素研究

目的:研究糖尿病及糖调节受损人群口腔念珠菌感染情况。方法:按照血糖水平将328例血糖异常的患者分为A组(糖尿病组)166例和B组(糖调节受损组)162例。另选择同期在我院门诊体检的血糖正常人群168例为(C组)对照组。统计受检者念珠菌携带、感染、阳性情况,记录受检者空腹血糖、唾液酸碱度、唾液流量,对唾液念珠菌阳性、感染的影响因素行Logistic回归分析。结果:A组口腔念珠菌感染率和阳性率均最高,高于B组和C组(P<0.01)。A组、B组唾液酸碱度、唾液流量均低于C组(均P<0.01)。A组空腹血糖水平最高,高于B组和C组(P<0.01),且B组空腹血糖水平高于C组(P<0.01)。结论:年龄、吸烟、配戴义齿和合并系统性疾病等因素与口腔念珠菌检测阳性及感染密切相关,为其主要危险因素。因此,念珠菌感染的高危人群应建立健康的生活习惯、密切监测血糖水平、保持口腔卫生,做好念珠菌感染的防治工作。

Clinical Study on Oral Candida Infection,Positive Rate and Influencing Factors in Patients with Diabetes and Impaired Glucose Regulation.

Objective: To study the oral Candida infection in population with impaired diabetes and glucose regulation. Methods: According to the blood glucose level, 328 cases were divided into group A (diabetic group) 166 cases and group B (impaired glucose regulation group) 162 cases. The normal population of blood sugar in 168 cases was set as control group (group C). Candida infection, the positive cases, subjects fasting blood glucose, the pH of saliva, salivary flow rate, effect on salivary Candida positive, infection factors were recorded and given Logistic regression analysis. Results: Oral Candida infection rate and positive rate was in group A the highest (P<0.01). The pH of saliva and salivary flow of group A and B were lower than those in group C (P<0.01). The fasting blood glucose level of group A was the highest, fasting blood glucose level of group B was higher than that in group C (P<0.01). Conclusion: Age, smoking, wearing dentures and associated with systemic disease factors and oral Candida positive detection and infection are closely related and are the main risk factors. Therefore, the high risk population of Candida infections should establish healthy habits, close monitoring of blood sugar levels, maintain oral hygiene, do a good job of Candida infection prevention and control work.