血清甘油三酯水平与抑郁症患者认知损伤的相关性

目的：探讨抑郁症患者认知损伤的特征及甘油三酯（triglyceride，TG）是否与抑郁症患者的认知功能损害具有相关性。方法：采用病例对照研究，纳入83例抑郁症患者（抑郁症组）和87例健康志愿者（对照组），使用重复性成套神经心理状态测验（RBANS）评估2组人群的认知功能，并测定其血清TG水平。结果：协方差分析结果显示抑郁症组的RBANS总分、言语功能得分、延迟记忆得分均显著低于对照组，差异有统计学意义（P＜0.01）。抑郁症组血清TG水平与RBANS总分（P＜0.01）、言语功能得分（P＜0.05）、注意功能得分（P＜0.05）、延迟记忆得分（P＜0.01）均存在负相关。多元线性回归结果显示抑郁症患者的血清TG水平是其RBANS总分（P＜0.05）、注意功能得分（P＜0.05）、延迟记忆得分（P＜0.01）的影响因素。结论：抑郁症患者存在认知损伤，尤其在言语和延迟记忆方面。血清TG水平升高会损害抑郁症患者的认知功能，特别是在注意和延迟记忆方面。

Association between serum triglyceride levels and cognitive function in depressive disorder

Objective: To investigate whether there are the characteristics of cognitive impairments in depressive patients, and to further examine whether serum triglyceride levels are associated with cognitive impairments in depressive patients. Methods: Eighty-three depressive patients and 87 healthy controls were enrolled in a case-control study. Cognitive function was assessed by RBANS in all subjects. Serum triglyceride levels were measured in both two groups. Results: Multivariate analysis of covariance showed that there were significantly lower cognitive function on the RBANS total score, the language index score, and the delayed memory index score in depressive patients than healthy controls (P<0.01). For the patients, serum triglyceride levels were negatively associated with the RBANS total score (P<0.01), the language index score (P<0.05), the attention index score (P<0.05), and the delayed memory index score (P<0.01). Further multivariate regression analysis showed that serum triglyceride levels were associated with the RBANS total score (P<0.05), the attention index score (P<0.05), and the delayed memory index score (P<0.01). Conclusion: Depressive patients have poorer cognitive function, especially in language and delayed memory. Moreover, the higher levels of serum triglyceride can cause cognitive impairments including attention and delayed memory in depressive patients.