预测局部晚期直肠癌新辅助放化疗疗效潜在的生物标记物

新辅助放化疗联合手术的治疗模式已成为局部晚期直肠癌（locally advanced rectal cancer，LARC）的标准治疗方案，准确预测新辅助放化疗后直肠肿瘤消退，特别是病理性完全缓解具有十分重要的意义，有助于为患者制定个体化治疗方案。因此，我们对可用于预测局部晚期直肠癌患者新辅助放化疗疗效的评价指标进行了综述和分析，并展望直肠癌放化疗疗效预测的进一步研究。

Potential predictors for neoadjuvant chemoradiation in locally advanced rectal cancer

Neoadjuvant chemoradiation followed by surgical treatment has become the standard treatment for LARC. Accurate prediction of rectal tumor regression after neoadjuvant chemotherapy, especially pathological complete remission, has been very important, which helps to develop individualized treatment plan for patients. Thus, potential predictors of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation are reviewed and analyzed here, and prospect of development of these predictor were discussed.