结直肠黏液腺癌病理学异质性及与预后的关系

探讨结直肠黏液腺癌临床病理及分子病理异质性。结合临床病理诊断积累的经验，并复习国内外相关文献，总结结直肠黏液腺癌的临床病理特征、微卫星不稳定性及对预后的影响。结直肠黏液腺癌病理形态特征及微卫星不稳定性状态方面的差异，导致不同的临床生物学行为，对治疗的反应及预后均不相同。结直肠黏液腺癌是一类异质性肿瘤，临床病理和分子病理相结合的精准病理诊断，有利于临床治疗方案的选择和预后分层。

The heterogenicity of mucinous colorectal adenocarcinoma and its association with prognosis

To discuss the heterogenicity of mucinous colorectal adenocarcinoma in respect of clinicopathological and molecular pathology. Review of the relevant literatures combining with our experience of pathological diagnosis, we summarize the morphological characteristics, the status of microsatellite and the effect on the prognosis of patients with mucinous colorectal adenocarcinoma. There are obvious difference among the morphological characteristics and the status of microsatellite in the patients with mucinous colorectal adenocarcinoma, which cause different clinic biologic behaviors, different response to treatment and so different prognosis. Mucinous colorectal adenocarcinoma is a kind of heterogeneous cancer. The precise diagnosis combining with the morphology and molecular pathology drawed by the pathologists, which is benefit to select the therapeutic regimen and helpful for prognostic stratification for the patients.