多发性骨髓瘤磁共振全身弥散加权成像临床应用价值

目的：探讨磁共振全身弥散加权成像（WBDWI）在多发性骨髓瘤中的应用价值。方法：使用GE Signa HDxt 3.0T磁共振成像仪，对21例多发性骨髓瘤患者行WBDWI检查，对阳性病灶进行双盲法诊断、分析，表观弥散系数（ADC）图像上测量ADC值。结果：WBDWI图像上多发性骨髓瘤均表现为弥漫性骨髓浸润改变，部位以胸骨、两侧肋骨、脊椎骨、骨盆及两侧股骨上段为主，病灶在MIP图像上表现为斑点状、斑片状高信号，翻转图像及ADC图像上表现为低信号。7例复查病例图像，6例病灶减少，MIP图像上高信号病灶的信号程度降低，ADC值升高。结论：WBDWI作为一种新的全身功能成像技术，在多发性骨髓瘤的诊断及疗效评价方面具有一定的应用价值。

The clinical value of MRI whole body diffusion weighted imaging in diagnosis of multiple myeloma#br#

Objective: To investigate the application value of MRI whole body diffusion weighted imaging (WBDWI) in diagnosis of multiple myeloma. Methods: Twenty one patients with multiple myeloma were underwent WBDWI by GE Signa HDxt 3.0T MR scaner. The positive results were diagnosed and analyzed by double-blind method, and the apparent diffusion coefficient (ADC) values of the lesions were measured on ADC imaging. Results: The diffuse infiltration of bone marrow were demonstrated in all cases of multiple myeloma on WBDWI images. The lesions mainly occurred in the sternum, ribs, vertebrae, pelvis and upper segment of the femur. The lesions showed mottled and patchy hyperintensity on MIP imaging, hypointensity on flipped imaging and ADC imaging. Of 7 cases with follow-up examination after treatment, 6 cases showed that the number of lesions reduced and the signal intensity decreased on MIP imaging, and the ADC values increased. Conclusion: As a new functional MR imaging technology, WBDWI has some application value in diagnosis and therapy evaluation of the multiple myeloma.