Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study. |
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| Authors: | S Ohira T Yamazaki H Hatano O Harada T Toki I Konishi |
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| Affiliation: | Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan. |
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| Abstract: | We describe an epithelioid trophoblastic tumor (ETT) metastatic to the vagina in a 30-year-old Japanese woman. A polypoid tumor in the vaginal orifice was composed of nests of intermediate trophoblastic cells that showed a striking epithelioid appearance. In the hysterectomy specimen, a tumor infiltrated through the myometrium and showed histologic findings similar to those of the vaginal tumor. The tumor cells were positive for cytokeratin, inhibin-alpha, and melanoma cell adhesion molecule (Mel-CAM, CD146) but were only focally positive for human placental lactogen. Electron microscopic examination revealed bundles of well-developed, intermediate-type filaments surrounding the nuclei. |
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