EFFECTS OF SOMATOSTATIN ANALOGUE SMS 201–995 IN NORMAL MAN |
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| Authors: | R R DAVIES MARGARET MILLER S J TURNER T H J GOODSHIP D B COOK M WATSON A McGILL H ØRSKOV K G M M ALBERTI D G JOHNSTON |
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| Institution: | Departments of Medicine and SAS Laboratory, Royal Victoria Infirmary, Newcastle upon Tyne, Department of Clinical Biochemistry, Newcastle General Hospital, Newcastle upon Tyne, Kommune Hospitalet, Aarhus, Denmark |
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| Abstract: | Long-acting somatostatin analogues may be of benefit in certain hypersecretory endocrine and gastrointestinal disorders. The 24 h hormonal and metabolic profiles of six normal male subjects receiving a twice daily subcutaneous injection of one such analogue SMS 201-995, 50 micrograms, has been compared to that obtained following placebo injection. Spontaneous daytime peaks of GH secretion were delayed until 1400 h following SMS 201-995 but nocturnal and total 24 h GH secretion were unaffected. The nocturnal rise in thyrotrophin was abolished by SMS 201-995 but thyroid function was unaffected. Insulin levels were suppressed following SMS 201-995 and the response to meals was inhibited. Glucose intolerance followed main meals. Glucagon levels were suppressed for up to 6 h. Circulating alanine levels were raised between 1200 h and 0600 h and there were intermittent elevations in lactate, pyruvate, glycerol and 3-hydroxybutyrate. Amino acid levels, including branched chain amino acids, were also increased. All six subjects suffered gastrointestinal side-effects. SMS 201-995, 50 micrograms, given twice daily shortly before meals does not suppress 24 h GH secretion, but demonstrates significant effects on metabolism and causes side effects in normal subjects. |
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