Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials |
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| Authors: | Steidl Rebecca Pearson Stacy Stephenson Robert E Ledala Nagender Sitthisak Sutthirat Wilkinson Brian J Jayaswal Radheshyam K |
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| Affiliation: | Department of Biological Sciences, Illinois State University, Normal, IL 61790-4120, USA. |
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| Abstract: | lacZ fusion strains were constructed using the promoters of five cell wall stress stimulon genes: pbp2, tcaA, vraSR, sgtB, and lytR. All fusion strains were induced only in the presence of cell wall-active antibiotics, suggesting the potential of these strains for use in high-throughput screening for new cell wall-active agents. |
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