| 表面增强激光解吸/离子化蛋白质芯片技术在肝细胞癌早期诊断研究中的应用 |
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| 引用本文： | 吴飞翔,王琪. 表面增强激光解吸/离子化蛋白质芯片技术在肝细胞癌早期诊断研究中的应用[J]. 医学综述, 2008, 14(13): 1963-1966 |
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| 作者姓名： | 吴飞翔 王琪 |
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| 作者单位： | 1. 广西医科大学附属肿瘤医院肝胆乳腺科,南宁,530021
2. 广西医科大学附属肿瘤医院实验研究部,南宁,530021 |
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| 摘 要： | 随着蛋白质组学研究技术的飞速发展,集样品分离、纯化、检测和数据分析为一体的表面增强激光解吸离子化飞行时间质谱蛋白质芯片技术已成为蛋白质组学研究的有力工具,它可以快速、简便地直接检测各种体液及分泌物,具有标本用量少、高通量分析等特点,并在筛选、鉴定肿瘤标志物及临床疾病的诊断、防治方面发挥了重要作用。本文介绍了该技术的特点和分析步骤,以及该技术在肝细胞癌早期诊断中的应用情况,并对其前景进行展望。
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| 关 键 词： | 蛋白质芯片 表面增强激光解吸/离子化飞行时间质谱 肝细胞癌 |
Application of Surface Enhanced Laser Desorption Ionization Proteinchip Technology in Diagnosis of Early Hepatocellular Carcinoma |
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| WU Fei-xiang,WANG Qi. Application of Surface Enhanced Laser Desorption Ionization Proteinchip Technology in Diagnosis of Early Hepatocellular Carcinoma[J]. Medical Recapitulate, 2008, 14(13): 1963-1966 |
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| Authors: | WU Fei-xiang WANG Qi |
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| Affiliation: | WU Fei-xiang1,WANG Qi2.(1.Department of Hepatobiliary , Brest,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China,2.Department of Experimental Research,China) |
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| Abstract: | With the rapid development of the research technique for proteomics,the protein chip technology of surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) has become a powerful tool in the research field of proteomics,which set separation,purification,detection and data analyses at the one machine and detect various samples rapidly and sensitively with little specimens and high-throughput ability.SELDI-TOF-MS has been demonstrated to play an important role in selection a... |
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| Keywords: | Proteinchip Surface enhanced laser desorption/ionization time-of-flight mass spectrometry Hepatocellular carcinoma |
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