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维儿康口服液的毒性试验及其病理组织学观察
引用本文:朱任之. 维儿康口服液的毒性试验及其病理组织学观察[J]. 兰州大学学报(医学版), 1996, 22(2): 1-3
作者姓名:朱任之
作者单位:兰州医学院病理学教研室
摘    要:维儿康口服液按50g/kg,10g/kg分别给大鼠灌胃90天,使动物体重增长加快,血红细胞计数和血红蛋白含量升高,但不影响白细胞计数和分类,血小板计数及肝,肾功能与脾,胸腺重量。给药组大鼠心,肝,脾,肺,肾外观形态及组织学表现亦无异常变化。

关 键 词:维儿康 口服液 毒性 病理组织学 中药学

The Toxicity Test for Weierkang Oral Liquid
Zhu Renzhi. The Toxicity Test for Weierkang Oral Liquid[J]. Journal of Lanzhou University (Medical Sciences), 1996, 22(2): 1-3
Authors:Zhu Renzhi
Abstract:he acute and long-term toxicity for new drug Weierkang(WEK)oral liquid were tested.The resultsshowed that WEK 50 or 10g/kg ig in rats for 90 days did not affect the function of liver and kidneys,butpromoted the growth of body weight,and increased RBC counts and HB content in rats.The pathologicalexamination revealed that the liver,heart,spleen,lungs and kidneys of rats were not changed inhistopathology and morphology on outward-appearance.The acute toxicity test in mice demonstrated thatthe maximal tolerable dosage for WEK was 200g/kg.which corresponds to 307.7 times of clinical dosagefor children.
Keywords:Weierkang oral liquid  Acute toxicity  Long-term toxicity  Rat  
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