血压节律变化对2型糖尿病患者下肢血管病变的影响

目的：探讨血压节律变化对2型糖尿病（T2DM）患者下肢血管病变的影响。方法选取本院收治的120例T2DM患者进行观察，其中伴下肢血管病变患者60例设为观察组（LEAD组），另60例非下肢血管病变的2型糖尿病患者设为对照组（非LEAD组），两组患者实施24 h无创性动态血压监测，对两组患者的血压节律变化进行对比分析。结果与非LEAD组比较， LEAD组患者24 hSBP、24 hPP、nSBP、nPP上升、夜间血压下降率减少等血压节律出现改变，两组比较差异有统计学意义（P〈0.05和P〈0.01）；非LEAD组患者杓型血压占68.33%， LEAD组杓型血压占36.67%，两组比较差异有统计学意义P〈0.01；LEAD组患者起床晨峰血压和起床前晨峰血压明显高于对照组（P〈0.05）。结论 T2DM患者下肢血管病变患者的昼夜血压变化强度大于非下肢血管病变患者，患者的夜间血压、血压晨峰均高于非下肢血管病变患者，下肢血管病变的危险性增加。

Effect of blood pressure rhythm changes on lower limb vascular lesion for patients with type 2 diabetes mellitus

Objective To study the effect of blood pressure rhythm changes on lower limb vascular lesion for patients with type 2 diabetes mellitus （T2DM）. Methods Choosing 120 T2DM patients in our hospital for observation, including 60 patients with lower extremity vascular lesions with patients as observation group （LEAD）, the other 60 cases of limb vascular lesions in patients with type 2 diabetes was set to the control group （not LEAD group）, two groups of patients with noninvasive 24 hours ambulatory blood pressure monitoring, rhythm changes on blood pressure in two groups of patients were analyzed. Results Compared with the LEAD group, LEAD group of 24 patients with HSBP, 24 HPP, nSBP, nPP increase, nighttime blood pressure decrease rate reduce blood pressure rhythm, such as change, comparing the two groups were statistically significant （P〈0.05, 0.01）;Not LEAD scoop type blood pressure group patients （68.33%）, LEAD group of scoop type blood pressure accounted for 36.67%, two groups are statistically significant （P〈0.01）; LEAD group of patients before blood pressure and got up morning get up early morning peak blood pressure significantly higher than control group, P〈0.05. Conclusion Circadian blood pressure variation of intensity of patients with T2DM and lower extremity vascular lesions is greater than the patients with lower extremity vascular lesions, nighttime blood pressure, blood pressure in patients with morning peak were higher than patients with lower extremity vascular lesions, increase the risk of lower limb vascular lesion.