扩张型心肌病患者2型糖尿病分布及脂毒性分析

目的探讨2型糖尿病（T2DM）及其继发的脂毒性在临床上具有扩张型心肌病（DCM）特点的心肌病变分布及其对患者心功能的影响。方法具有扩张型心肌病变特点患者共259例,分析其T2DM患病情况及血清游离脂肪酸（FFA）水平,了解T2DM及FFA对DCM患者心功能的影响。结果 DCM患者,特别是继发性者,具有较高的T2DM患病率,合并T2DM及高FFA水平的DCM患者心功能较差。结论 DCM患者具有较高的T2DM患病率及其继发的脂毒性,临床工作中应引起重视。

Distribution of type 2 diabetes mellitus and analysis of lipotoxicity in patients with dilated cardiomyopathy

Objective To investigate the distribution of type 2 diabetes mellitus （T2DM）, myocardial lesions with features of dilated cardiomyopathy （DCM） and secondary lipotoxictty, and the influence on patients＇ cardiac function. Methods A total of 259 patients with DCM were enrolled. Their T2DM situation and serum free fatty acid （FFA） level were analyzed, so as to get to know the influence of T2DM and FFA on patients with DCM. Results Incidence of T2DM was high in patients with DCM, especially in those with secondary DCM. The cardiac function of DCM patients with T2DM combined with high levels of FFA was poor. Conclusion The morbidity of T2DM and its secondary lipotoxicity are high in patients with DCM, and it should be serious considered in clinical work.