| 孕期脂多糖刺激诱导子代大鼠高血压的机制研究 |
| |
| 引用本文： | 郝雪琴,孔涛,李晓辉. 孕期脂多糖刺激诱导子代大鼠高血压的机制研究[J]. 重庆医学, 2011, 40(5): 445-447,521. DOI: 10.3969/j.issn.1671-8348.2011.05.012 |
| |
| 作者姓名： | 郝雪琴 孔涛 李晓辉 |
| |
| 作者单位： | 河南科技大学动物科技学院药理学教研室;第三军医大学药学院药剂学教研室; |
| |
| 摘 要： | 目的 探讨孕期脂多糖刺激诱导子代大鼠(简称子鼠)高血压的机制研究.方法 将SD孕鼠6只随机分为两组.对照组 3只:腹腔注射无菌生理盐水 0.5 mL;脂多糖组 3只:腹腔注射脂多糖,剂量为0.79 mg/kg.分别在孕期第8、10、12天08∶00～09∶00 进行腹腔注射.子鼠出生后,观察7～25周龄子鼠血压的变化和...
|
| 关 键 词： | 炎症 脂多糖类 肾素-血管紧张素系统 高血压 |
Effects of maternal lipopolysaccharide on intrarenal renin-angiotensin system in offspring rats |
| |
| Hao Xueqin,Kong Tao,Li Xiaohui. Effects of maternal lipopolysaccharide on intrarenal renin-angiotensin system in offspring rats[J]. Chongqing Medical Journal, 2011, 40(5): 445-447,521. DOI: 10.3969/j.issn.1671-8348.2011.05.012 |
| |
| Authors: | Hao Xueqin Kong Tao Li Xiaohui |
| |
| Affiliation: | Hao Xueqin1,2,Kong Tao1,Li Xiaohui2(1.Department of Pharmacology,Animal Science and Technology College,Henan University of Science and Technology,Luoyang,Henan 471003,China,2.Department of Pharmaceutics,Pharmaceutical College,Third Military Medical University,Chongqing 400038,China) |
| |
| Abstract: | Objective To explore the mechanism of hypertension caused by maternal exposure to lipopolysaccharide in adult offspring rats.Methods Nulliparous,pregnant,time-matched SD rats were randomly divided into two groups(n=3):control group and LPS group.On the pregnant day 8,10 and 12,rats in control group and LPS group were administered intraperitoneally with saline 0.5 mL or LPS 0.79 mg/kg,respectively.The systolic blood pressure was measured in offspring once three weeks from 7 weeks of age to 25 weeks of age.Th... |
| |
| Keywords: | inflammation lipopolysaccharides offspring renin-angiotensin system hypertension |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
