| 不同时期糖尿病肾病患者血浆ET-1和CGRP含量变化及其临床意义 |
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| 引用本文： | 杨丕坚,吕以培,李舒敏,黄中莹,黄虹.不同时期糖尿病肾病患者血浆ET-1和CGRP含量变化及其临床意义[J].重庆医学,2011,40(5):462-463. |
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| 作者姓名： | 杨丕坚 吕以培 李舒敏 黄中莹 黄虹 |
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| 作者单位： | 广西壮族自治区钦州市第二人民医院内分泌科; |
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| 摘 要： | 目的探讨不同时期糖尿病肾病(diabetic nephropathy,DN)患者血浆内皮素-1(ET-1)、降钙素基因相关肽(CGRP)的水平变化,以阐明其在DN的作用。方法选择2型糖尿病患者160例,按照蛋白尿及肾功能将DN分期:无蛋白尿期40例,微量蛋白尿期40例,临床蛋白尿期40例,肾功能不全期40例。与正常人及糖调节异常期各40例作对比,检测血浆ET-1、CGRP的浓度并进行对比分析。结果 DN不同时期患者、糖尿病前期患者血浆ET-1、CGRP浓度与正常人相比差异均有统计学意义(P<0.01)。结论随着DN的进展,血浆ET-1含量升高,CGRP含量降低,并且与DN病变严重程度相关,血浆ET-1和CGRP含量检测有助于判断病情的程度。
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| 关 键 词： | 糖尿病 2型 糖尿病肾病 降钙素基因相关肽 内皮素-1 |
Clinical significance of changes of ET-1 and CGRP contents in different period of diabetic nephropathy |
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| Yang Pijian,Lv Yipei,Li Shumin,Huang Zhongying,Huanghong.Clinical significance of changes of ET-1 and CGRP contents in different period of diabetic nephropathy[J].Chongqing Medical Journal,2011,40(5):462-463. |
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| Authors: | Yang Pijian Lv Yipei Li Shumin Huang Zhongying Huanghong |
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| Institution: | (Department of Endocrinology,the Second People′s Hospital of Qinzhou,Qinzhou,Guangxi 535000,China) |
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| Abstract: | Objective To illustrate the effects of endothelin-1(ET-1) and calcitonin gene related peptide(CGRP) in different period diabetic nephropathy(DN) through investigation of the changes of the plasma levels o f ET-1 and CGRP.Methods 160 patients with type 2 diabetes mellitus(T2DM) were divided into 40 cases without microalbuminuria period,40 cases with microalbuminuria period,40 cases overt proteinuria period,40 cases impaired renal function period according to level of microalbuminuria and renal function,and c... |
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| Keywords: | diabetes mellitus type 2 diabetic nephropathies calcitonin gene-related peptide endothelin-1 |
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