线粒体氧毒性损伤及氢气的拮抗作用

高分压氧产生的过量活性氧自由基是导致氧毒性的最主要损伤机制,这限制了氧在临床上的广泛应用。线粒体是氧代谢的主要场所,这使其成为活性氧自由基产生及引起损伤的主要部位,而线粒体的严重损伤会导致细胞死亡。近年研究证实氢气能够选择性地清除毒性作用极强的自由基,对高分压氧毒性所致的线粒体损伤有保护作用,从而保护细胞免受自由基损害。该文重点阐述高分压氧毒性所致的线粒体损伤及氢气的拮抗作用。

Mitochondrial Damage in Hyperoxia Toxicity and Antagonistic Effect of Hydrogen

Excessive reactive oxygen species generated by hyperoxia are the main reasons of oxygen toxicity,which limit the clinical application of oxygen.Mitochondria are the main place of oxygen metabolism,which makes it the primary producing and damaging target of reactive oxygen species.What′s more,serious damage of mitochondrial can lead to cell death.It has been proved that hydrogen has a selective anti-oxidation effect,which can protect the mitochondria from damage induced by hyperoxia and cells from free radicals.Here is to make a review on mitochondrial damage and the antagonistic effect of hydrogen in hyperoxia toxicity.