丹参水煎液外用对皮肤创伤的影响

目的 探讨丹参水煎液外用对大、小鼠创伤性溃疡及豚鼠阳性疮疡模型的影响。方法 皮下注射稀盐酸造小鼠创伤性溃疡模型；特制致伤器在脊柱右侧打孔造大鼠创伤性溃疡模型；感染金黄色葡萄球菌造豚鼠阳性疮疡模型。观察丹参水煎液对大、小鼠创伤性溃疡模型创伤面积及病理变化的影响，对豚鼠阳性疮疡模型中血清溶菌酶含量及局部病理变化的影响。结果 3种模型建立成功，丹参水煎液可显著减少大、小鼠创伤面积，显著升高模型豚鼠血清中的溶菌酶含量，显著改善各模型动物的组织病理学变化。结论 丹参水煎液外用对大、小鼠创伤性溃疡及豚鼠阳性疮疡有较好的治疗作用。

External Curative Effect of Salviae Militiorrhizae Radix Decoction on Skin Wounds

OBJECTIVE To investigate the local external curative effect of Salviae Militiorrhizae Radix decoction on skin wounds of mice and rats as well as guinea pigs. METHODS The traumatic ulcer models in mice, rats and guinea pigs were established with hydrochloric acid injection, punchering, and Staphylococcus aureus injection, respectively. The effect of Salviae Militiorrhizae Radix decoction on the wound area of mice, rats and the content of lysozyme in the serum of guinea pig along with respective pathological changes were observed. RESULTS The three kinds of model were totally established successfully. After treated with Salviae Militiorrhizae Radix decoction, the wound area of mice and rats reduced remarkably; the content of muramidase in the blood serum of guinea pig increased remarkably; simultaneously the damaged skin repaired remarkably. CONCLUSION External application of the Salviae Militiorrhizae Radix decoction has positive effect on curing skin ulcer of animal models.