急性肾损伤早期标志物及其在体外循环术后应用的研究进展

急性肾损伤(AKI)是体外循环心脏手术后常见而又严重的并发症,早期发现AKI并及时进行干预治疗影响着患者的预后。传统的AKI诊断指标为血清肌酐水平上升,但血清肌酐的上升往往发生在AKI出现后的48～72 h,不利于AKI的早期诊断。近来越来越多的研究发现,中性粒细胞明胶酶相关性脂质运载蛋白、肾损伤分子1、胱抑素C、白细胞介素(IL)18、IL-6、IL-8、脂肪酸结合蛋白、神经生长因子1等的检测可能会更早地预测AKI的发生。

Research Advance in Early Biomarkers of Acute Kidney Injury and Its Application after Cardiopulmonary Bypass

Acute kidney injury(AKI)is a common and serious complication after cardiopulmonary bypass(CPB),the early detection of the presence of AKI and timely intervention affect the postoperative prognosis of patients.Traditional diagnostic indicator is the serum creatinine level,which increases within 48 to 72 hours after AKI,not soon enough for early diagnosis.Recently,a growing number of studies found that NGAL,KIM-1,Cys-C,IL-18,IL-6,IL-8,FABPs and Netrin-1 may be earlier predictive biomarkers of AKI.