|
|||||
|
|
| 云南五个少数民族的CSF1PO、TPOX和TH01基因座遗传多态性研究 | |
| 引用本文： | 邹苹,邹浪萍,申滨,杨燕,李德林,褚嘉档. 云南五个少数民族的CSF1PO、TPOX和TH01基因座遗传多态性研究[J]. 中华医学遗传学杂志, 2002, 19(4): 332-335 |
| 作者姓名： | 邹苹 邹浪萍 申滨 杨燕 李德林 褚嘉档 |
| 作者单位： | 1. 650031,昆明市妇幼保健医院 2. 云南省高级人民法院司法鉴定科学技术研究所 3. 昆明医学院 4. 中国医学科学院医学生物学研究所 |
| 基金项目： | 国家自然科学基金 (39760 0 35、3999342 0 )，美国中华医学基金 CMB项目 (98- 675)~~ |
| 摘 要： | 目的 了解云南阿昌族、德昂族、布朗族、普米族和基诺族等5少数民族的CSF1PO、TPOX和TH01基因座遗传多态性分布。方法 应用复合扩增技术对CSF1PO、TPOX和TH01等3个短串联重复序列（short tandem repeat,STR）基因座进行扩增，采用高分辨率的聚丙烯酰胺凝胶电泳分离、银染法显影技术，对云南上述5个少数民族的基因座进行遗传多态性调查。结果 获得了云南省特有的阿昌族、德昂族、布朗族、普米族和基诺族等5个少数民族的CSF1PO、TPOX和TH013个基因座的基因频率分布资料。结论 CSF1PO、TPOX和TH013个基因座基因频率分布与Hardy-Weinberg平衡吻合良好，在不同群体中发现一些有意义的遗传差异。 |
| 关 键 词： | CSF1PO TPOX TH01 中国少数民族 基因座 遗传多态性 复合扩增技术 |
| 修稿时间： | 2001-06-11 |
Distribution of CSF1PO,TPOX and TH01 loci in five minority populations in Yunnan of China |
|
| ZOU Ping ,ZOU Langping ,SHEN Bing ,YANG Yan ,LI Delin ,CHU Jiayou .. Distribution of CSF1PO,TPOX and TH01 loci in five minority populations in Yunnan of China[J]. Chinese journal of medical genetics, 2002, 19(4): 332-335 | |
| Authors: | ZOU Ping ZOU Langping SHEN Bing YANG Yan LI Delin CHU Jiayou . |
| Affiliation: | Maternal and Child Health Hospital of Kunming, Kunming, Yunnan, 650031 P.R.China. zlp1958@public.km.yn.cn |
| Abstract: | Objective To investigate the distribution of CSF1PO, TPOX and TH01 in 5 minority populations only resided in Yunnan province. Methods DNA extraction from bloods and multiplex amplification of CSF1PO, TPOX and TH01 were carried out. The technique of denaturing polyacrylamide gel electrophoresis and silver staining method were used. Results The data on the distribution of allele frequencies of 3 loci(CSF1PO, TPOX and TH01) in Achang,Deang,Bulang,Pumi and Jino were collected and analyzed. Conclusion The allele distribution of the loci were in good agreement with the Hardy Weinberg equibrium. A satisfactory result was obtained and some significant genetics differences were noticed in different populations. |
| Keywords: | minority population of China loci genetics ploymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |