Identification and nucleotide sequence of HLA-A*03013 |
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Authors: | Guttridge M G Darke C |
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Institution: | Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Cardiff, Wales, UK. martin.guttridge@wbs.nhs.uk |
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Abstract: | We have identified a further HLA-A*03 allele, A*03013, in three unrelated Caucasoid individuals. The allele was initially detected by the polymerase chain reaction using sequence-specific primers (PCR-SSP) and was shown to differ from HLA-A*03011 by a single non-coding substitution of G to T at position 167 in exon 2 by DNA sequencing. The A*03013 bearing haplotype in one of the three individuals, was HLA-A*03013, B*07, Cw*0702, DRB1*1101, DRB3*0202, DQA1*05, DQB1*0301. The estimated phenotype and gene frequencies for A*03013 was <0.02% and <0.00007, respectively. |
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Keywords: | HLA-A*03 PCR-SSP HLA-A*03013 |
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