| CYP1A1和GSTM1基因多态性与肺癌易感性的Meta分析 |
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| 引用本文： | 苏艳华,王小利,徐顺清.CYP1A1和GSTM1基因多态性与肺癌易感性的Meta分析[J].肿瘤防治研究,2006,33(5):324-327. |
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| 作者姓名： | 苏艳华 王小利 徐顺清 |
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| 作者单位： | 华中科技大学同济医学院环境医学研究所; |
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| 摘 要： | 目的探讨CYP1A1和GSTM1基因多态性与个体肺癌易感性的关系。方法全面检索相关文献,应用Meta分析方法对各研究进行数据的合并与分析。结果共8篇文献入选,累计肺癌病例1067人,对照1416人,分别对CYP1A1*A和GSTM1-、CYP1A1*B/C和GSTM1+、CYP1A1*B/C和GSTM1-联合基因型进行统计分析。异质性检验χ2值分别为6.43、8.83与9.63,P>0.05,文献有同质性,各合并OR及95%CI分别为1.36(1.09~2.77)、1.65(1.26~2.15)和2.01(1.57~2.59)。结论CYP1A1和GSTM1突变基因型为罹患肺癌的易感基因型,且两者存在协同作用,在肿瘤防治方案中应加以重视从而采取相应措施达到有效预防肿瘤的目的。
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| 关 键 词： | 肺癌 CYP1A1基因 GSTM1基因 多态性 Meta分析 |
| 文章编号： | 1000-8578（2006）05-0324-04 |
| 收稿时间： | 2005-04-07 |
| 修稿时间： | 2005-04-072005-10-25 |
The Polymorphisms of CYP1A1 and GSTM1 Genes on Individual Susceptibility to Lung Cancer: Meta-analysis |
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| SU Yan-hua,WANG Xiao-li,XU Shun-qing.The Polymorphisms of CYP1A1 and GSTM1 Genes on Individual Susceptibility to Lung Cancer: Meta-analysis[J].Cancer Research on Prevention and Treatment,2006,33(5):324-327. |
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| Authors: | SU Yan-hua WANG Xiao-li XU Shun-qing |
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| Institution: | The Institute of Environmental Medicine; Tongji Medical College; Huazhong University of Science and Technology; Wuhan 430030; China; |
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| Abstract: | Objective To study the relationship between the polymorphisms of CYP1A1 and GSTM1 genes and the individual susceptibility of lung cancer.Methods To search all the data about the subjects,and to process all the related data by means of Meta-analysis.Results A total of 1067 cases and 1416 controls from 8 studies were included.The analysis for homogeneity (Q statistics test) showed that all eligible studies were homogeneity. Taking the risk of the genotypes CYP1A1* A and GSTM1+ as baseline for analysis,the ORs... |
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| Keywords: | Lung cancer CYP1 A1 gene GSTM1 gene Polymorphisms Meta analysis |
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