| COX-2和VEGF在人脑星形细胞瘤中的表达及与临床病理分级的相关性 |
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| 引用本文： | 徐滨,宋来君,徐国本,张智峰. COX-2和VEGF在人脑星形细胞瘤中的表达及与临床病理分级的相关性[J]. 基础医学与临床, 2006, 26(10): 1089-1092 |
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| 作者姓名： | 徐滨 宋来君 徐国本 张智峰 |
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| 作者单位： | 郑州大学,第一附属医院,神经外科,河南,郑州,450052;郑州大学,第一附属医院,神经外科,河南,郑州,450052;郑州大学,第一附属医院,神经外科,河南,郑州,450052;郑州大学,第一附属医院,神经外科,河南,郑州,450052 |
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| 摘 要： | 目的探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在人脑星形细胞瘤中的表达及其与肿瘤临床病理分级的关系。方法通过免疫组化SP法测定COX-2和VEGF在50例人脑星形细胞瘤和10例正常脑组织中的表达。结果COX-2、VEGF在人脑星形细胞瘤中的表达高于正常脑组织(P<0.001)。COX-2和VEGF与人脑星形细胞瘤临床病理分级显著相关(P<0.05)。人脑星形细胞瘤中COX-2与VEGF的表达存在相关性。结论COX-2和VEGF参与人脑星形细胞瘤的发生、发展且与其恶性表型有关;COX-2可能与人脑星形细胞瘤的血管形成有关。
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| 关 键 词： | 星形细胞瘤 环氧化酶-2 血管内皮生长因子 免疫组化 |
| 文章编号： | 1001-6325(2006)10-1089-04 |
| 收稿时间： | 2005-09-15 |
| 修稿时间： | 2006-04-20 |
Expression of COX-2 and VEGF in human astrocytomas and its relations with pathological grades |
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| X Bin,SONG Lai-jun,X Guo-ben,ZHANG Zhi-feng. Expression of COX-2 and VEGF in human astrocytomas and its relations with pathological grades[J]. Basic Medical Sciences and Clinics, 2006, 26(10): 1089-1092 |
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| Authors: | X Bin SONG Lai-jun X Guo-ben ZHANG Zhi-feng |
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| Affiliation: | Department of Neuroeurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | Objective To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) and their relationships with the pathological characteristics of human astrocytomas.Methods Immunohistochemistry method was used to investigate the expression of COX-2 and VEGF among human astrocytoma samples(n=50) and normal brain tissue (n=10) respectively.Results The positive rate of COX-2 and VEGF was different between the human astrocytomas and normal brain tissue(P<0.01).The expression of COX-2 in human astrocytomas was related to the tumor's pathological grades(P<0.05).The expression of VEGF was closely associated with COX-2(P<0.01).Conclusions COX-2 and VEGF may be involved in gliomas'occurance and development.Expression of COX-2 and VEGF protein was positively correlated with malignant phenotype of gliomas. |
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| Keywords: | human astrocytomas cyclooxygenase-2 vascular endothelial growth factor immunohistochemistry |
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