神经氨酸酶抑制剂抗流感病毒的研究进展

  神经氨酸酶(NA)是流感病毒表面一种蘑菇云状四聚体结构的包膜糖蛋白,其抑制剂对高致病性流感病毒的各亚型均具有抑制作用,且其安全性和耐药性良好,可用于流感病毒的预防和治疗。笔者在归纳总结近年来该领域国内外文献的基础之上,对神经氨酸酶及其抑制剂的分类、构效关系以及国内外研究现状进行总结,有助于我们更好地利用现有条件设计并合成出活性更好、选择性更高的抗流感药物。

Advances in Anti-Influenza Virus of Neuraminidase Inhibitors

Neuraminidase (NA) is a mushroom-shaped and tetramer structural envelope glycoprotein on the surface of the influenza virus.NA inhibitors can inhibit highly pathogenic influenza virus subtypes and have good safety and drug resistance, hence they are widely used for the prevention and treatment of influenza virus.Based on the present domestic and foreign literatures in this field, this paper summarizes the research status of neuraminidase inhibitors classification and structure-activity relationships.It will help us make better use of existing conditions to design and synthesize better active and more selective anti-influenza drugs.