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| 口腔贴膜表面粗糙度对黏膜黏附性能的影响 | |
| 引用本文： | 许珊珊,雷艳丽,陈晶,,刘晨,,隋宏,,王文苹,. 口腔贴膜表面粗糙度对黏膜黏附性能的影响[J]. 中国药学杂志, 2015, 50(4): 344-347. DOI: 10.11669/cpj.2015.04.017 |
| 作者姓名： | 许珊珊 雷艳丽 陈晶 刘晨 隋宏 王文苹 |
| 作者单位： | 1.宁夏医科大学药学院 银川 750004; 2.宁夏医科大学附属总医院制剂中心, 银川 750004; 3.宁夏回药现代化工程技术研究中心, 银川 750004; 4.回医药现代化省部共建教育部重点实验室, 银川 750004 |
| 基金项目： | 国家自然科学基金资助项目(81160521);宁夏自然科学基金资助项目(NZ1226) |
| 摘 要： | 目的 探讨口腔贴膜不同表面粗糙度与黏膜黏附性能之间的关系。方法 以不同粗糙度的砂纸为母版制作聚二甲基硅氧烷反模板,并进一步采用流延法制备口腔贴膜。观察所得贴膜微观形态,并分别测定其体外黏附力、剪切力及黏附时间。结果 壳聚糖贴膜的黏膜黏附性能较优于白及胶贴膜。表面粗糙度不同的贴膜之间体外黏附性能差异显著,其中#400贴膜的性能最优。结论 表面粗糙度对口腔贴膜的体外黏膜黏附性能存在显著影响,值得进一步研究。 |
| 关 键 词： | 口腔贴膜 黏附性能 表面粗糙度 |
| 收稿时间： | 2015-03-09; |
Effect of Surface Roughness on Mucosal Adhesion Properties of Oral Film |
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| XU Shan-shan,LEI Yan-li,CHEN Jing,,LIU Chen,,SUI Hong,,WANG Wen-ping,. Effect of Surface Roughness on Mucosal Adhesion Properties of Oral Film[J]. Chinese Pharmaceutical Journal, 2015, 50(4): 344-347. DOI: 10.11669/cpj.2015.04.017 | |
| Authors: | XU Shan-shan LEI Yan-li CHEN Jing LIU Chen SUI Hong WANG Wen-ping |
| Affiliation: | 1.School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China; 2.General Hospital of Ningxia Medical University, Yinchuan 750004, China; 3. Ningxia Engineering & Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China; 4.Key Lab of Hui Ethnic Medicine Modernization, Ministry of Education, Yinchuan 750004, China |
| Abstract: | OBJECTIVE To study the relationship between surface roughness and muc-oadhesion properties of oral film. METHODS Polydimethylsiloxane reverse templates were fabricated from sandpapers with different roughness, and were used as the m-old to prepare films by solvent casting method. The obtained films were then evaluat-ed for mucoadhesive force, shear force, mucoadhesion time, and their morpholog-y was investigated by scanning electron microscopy (SEM). RESULTS Films of c-hitosan showed more favorable mucoadhesive performance than those of Bletilla striata gum. Generally, the prepared films exhibited different mucoadhesion properties, among which #400 films showed the best performance. CONCLUSION The mucoadhesion prop-erties of films were significantly affected by their surface roughness, which are wo-rthy of further study. |
| Keywords: | oral film mucoadhesion properties surface roughness |
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