丙戊酸和碳青霉烯类抗菌药的相互作用研究进展

为评估丙戊酸和碳青霉烯类抗菌药之间相互作用的机制,本文通过在Pubmed上检索关于丙戊酸与碳青霉烯类抗菌药相互作用的文献,并进行归纳分析,发现两药相互作用的机制在丙戊酸的吸收、分布、代谢和排泄方面均有作用。丙戊酸和碳青霉烯类抗菌药合用会导致丙戊酸的血药浓度下降,引起癫痫的再发作,因此临床上应该避免丙戊酸和碳青霉烯类抗菌药的联合使用,以保障临床用药安全。

Advances of the Interaction between Valproic Acid and Carbapenem Antibiotics

To critically evaluate the mechanisms of the interaction between valproic acid and carbapenem antibiotics. Research about the interaction between valproic acid and carbapenem antibiotics related case reports those were indexed from the Pubmed database. Studies to explain the decrease were carried out using rats and monkeys by the following mechanism: absorption, distribution, metabolism, and excretion of valproic acid. Carbapenem antibiotics induced a decrease of plasma concentration of valproic acid in epileptic patients during valproic acid therapy, resulting in the recurrence of epileptic seizures. Therefore, therapy with valproic acid and carbapenem antibibiotics should be avoided.