Second HLA-A*68 null allele,A*6818 N,identified |
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Authors: | Dormoy A Froelich N Parissiadis A Cazenave J-P Tongio M M |
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Institution: | Etablissment Fan?ais du Sang-Alsace, Starsbourg, France. anne.dormoy@etss.u-strasbg.fr |
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Abstract: | A second HLA-A*68 null allele, HLA-A*6818 N, was identified in our laboratory after discrepant results were obtained between class I serological and molecular typing in a male patient suffering from narcolepsy. HLA-A*6818 N displays a sequence identical to that of the HLA-A*6802 allele, except in exon 2 where 20 nucleotides inserted at codon position 48 are a repeat of the 20 preceding nucleotides. This duplication creates a shift of the reading frame, which leads to a premature non-sense codon at position 59 of the null allele. |
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