尿微量白蛋白在糖尿病和高血压肾病早期诊断中的应用

目的探讨尿微量白蛋白(UMA)在糖尿病肾病(DN)和高血压肾病早期的诊断价值。方法将研究对象分为糖尿病无合并症组、糖尿病肾病血压正常组、糖尿病肾病高血压组和普通高血压病组,测定UMA和血BUN、Cr含量。结果 DN和高血压肾病患者UMA含量和阳性率明显增高,且与病程和年龄密切相关,r值分别为0.436-0.663和0.415-0.832,病程越长,年龄越大,增高越显著(P0.05-P0.001),而与性别无关(P0.05);随高血压分级的增加,UMA含量和阳性率明显增加;DM各组Cr和BUN含量和阳性率也升高,反映DN和高血压肾病指标的敏感性依次为UMACrBUN。结论 UMA检测对DM和高血压患者的早期肾损伤有预测价值,动态监测有助于DN和高血压肾病的早期诊断。

Application of Detection Urine Minimum Albumin in the Early Diagnosis of Diabetic Nephropathy and Hypertension Nephropathy

Objective To study the relation between urine-micro-albumin（UMA） and diabetes nephritis（DN） as well as hypertension nephritis.Methods The volunteers were divided into 4 groups：Diatetes without complication;Diatetes nephritis with normal blood tension;Diatetes nephritis with hypertension;Hypertension.UMA,blood BUN,and content of Cr were tested.Results For DN and hypertension nephritis patients,the content of UMA and its active rate increased significantly,which was related to the course（r=0.436-0.663）,the longer the course is,the more significant it is（P0.05-P0.001,r=0.415-0.832）,and there is no significance between 2 sexes（P0.05）;content of UMA and its active rate increase as blood pressure increases.;content of Cr and BUN as well as its active rate increase for groups with DN,which reflects that the senceptibility for DN and hypertension nephritis is UMACrBUN.Conclusion testing of UMA is valuable for pre-estimate of DM and early kidney injury for hypertension patients,and its monitoring is helpful for early diagnosis of DN and hypertension nephritis.