| 81对习惯性流产夫妇的染色体分析 |
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| 引用本文： | 魏若璋,郑增淳,彭惠民.81对习惯性流产夫妇的染色体分析[J].重庆医科大学学报,1988(1). |
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| 作者姓名： | 魏若璋 郑增淳 彭惠民 |
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| 作者单位： | 重庆医科大学生物学教研室
(魏若璋，郑增淳)，重庆医科大学生物学教研室(彭惠民) |
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| 摘 要： | 本文对81对习惯性流产夫妇进行了染色体研究,发现4例染色体异常,其中3例为相互易位携带者,1例为罗伯逊易位携带者,核型分别为46,xx,t(4;5)(q_(35);q_(31));46,xx,t(6;13)(P_(23);q_(22));45,xx,t(13;13)(p_(11);q_(11));46,xx,t(2;13)(q_(37);q_(22)).讨论了平衡染色体重排的断裂点,热点与染色体脆性部位三者之间的关系,分析了平衡易位是导致习惯性流产的染色体异常的一种主要形式
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| 关 键 词： | 染色体 平衡易位 习惯性流产 断裂点 染色体重排 |
CHROMOSOME ANALYSIS IN 81 COUPLES OF HABITUAL ABORTION |
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| Institution: | Department of Biology: Wei Ruozhang,Zheng zengchun,Peng Huiming |
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| Abstract: | Chromosome analysis were studied from 81 couples(162 cases), who had two or more spontaneous abortions. Four cases of them showed chromosome abnarmalities(2.47%). All of them showed balanced translocation. The karyotypes are 46, xx, t(4; 5)(q35; q31), 46, xx, t(6; 13) (p23; q22); 45, xx, t(13; 13) (p11; q11); 46, xx, t(2; 13) (q37; q22). The results indicated that balanced chromosome rearrangement is the chief form of chromosome abnormalities and being carriers to cause abortion. |
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| Keywords: | Chromosome Balanced translocation Habitual abortion Break-points Chromosome Rearrangement |
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