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突变型P53的存在状态与不同化疗药物敏感性相互性的研究
引用本文:谭亚君,楼滨,陈瑜. 突变型P53的存在状态与不同化疗药物敏感性相互性的研究[J]. 全科医学临床与教育, 2006, 4(6): 485-487
作者姓名:谭亚君  楼滨  陈瑜
作者单位:310003,浙江杭州,浙江大学医学院附属第一医院检验科
摘    要:目的 研究胃癌细胞中突变型P53的存在状态与不同化疗药物敏感性的相互关系。方法 将突变型P53、sv40Tag(封闭P53)导入胃癌细胞株SGC.7901中,用MTI法比较各组细胞对化疗药的敏感性。结果 导入突变型P53细胞株对5-氟脲嘧啶(5-F)耐药性较导入竞变型P53+sv40Tag细胞株及对照组差异均有统计学意义(P〈0.05)。导入突变型P53细胞株和导入突变型P53+sv40Tag细胞株对阿霉素(ADM)耐药性较对照组差异均有统计学意史(P〈0.05)。导入突变型P53细胞株、导入突变型P53+sv40Tag细胞株及对照组细胞株各组对顺铂(CDDP)耐药性差异均有统计学意义(P〉0.05)。结论 突变型P53与肿瘤细胞对化疗药敏感性有一定的相关性。

关 键 词:胃癌细胞  突变型P53  化疗药  敏感性
收稿时间:2006-06-29
修稿时间:2006-06-29

Relationship between the P53 functional status of human tumor cell lines and their chemosensitivities to different anticancer drug
TAN Yajun,LOU Bin,CHEN Yu. Relationship between the P53 functional status of human tumor cell lines and their chemosensitivities to different anticancer drug[J]. clinical education of general practice, 2006, 4(6): 485-487
Authors:TAN Yajun  LOU Bin  CHEN Yu
Abstract:Objective To explore the relationship between mutant P53 status and multidrug resistance in gastric cancer.Methods Mutant P53(mP53)and mP53+ sv40 Tag were transferred to gastric cancer cell line SGC-7901.The difference in chemotherapeutic sensitivity of SGC-7901 cells with mutant P53 was compared with those with mP53+ sv40 Tag and controls by MTT method.Results SGC-7901 cells with mutant P53 showed higher chemotherapeutic sensitivity to 5-Fu than that with mP53+ sv40 Tag and control( P<0.05).SGC-7901 cells with mutant P53 and those with mP53+ sv40 Tag showed higher chemotherapeutic sensitivity to ADM than control( P<0.05).There was no difference in chemotherapeutic sensitivity of SGC-7901 cells with mutant P53 compared with those with mP53+ sv40 Tag and control to CDDP( P>0.05).Conclusion Mutant P53 genesis closely related to their chemosensitivities to different anticancer drug in gastric cancer.
Keywords:stomach neoplasm   mutant P53   antlcaneer drug   chemosensitivity
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