内源性一氧化碳与慢性肺心病关系的研究

目的探讨内源性一氧化碳(CO)在慢性肺心病发病过程中的作用.方法分别测定30例慢性肺心病患者急性加重期和缓解期血浆CO水平,并分别将其与反映肺动脉压的超声指标右室射血前时间与肺动脉血流加速时间的比值(RVPEP/AT)及动脉血氧分压(PaO2)进行相关分析.结果肺心病组急性加重期和缓解期血浆CO水平明显高于正常对照组(P均＜0.001),与PaO2呈负相关,与RVPEP/AT呈正相关.结论肺心病患者血浆内源性CO水平升高,其升高程度与肺动脉压增高及PaO2降低的程度相一致,提示内源性CO参与了肺动脉压的调节,在肺心病发生过程中起重要作用.

Study on the relationship between endogenous carbon monoxide with chronic pulmonary heart disease

ve To explore the relationship between endogenous carbon monoxide(CO) with chronic pulmonary heart disease(CPHD). Methods To measure the plasma CO levels in 30 patients with CPHD and investigate the relationship between them with PaO2 and the ratio of right ventricular prejection period (RVPEP) to the pulmonary flow acceleration time (AT). Results The plasma CO levels in the acceleration and remission stages of CPHD group were both higher than those in control group( P <0. 001); In CPHD group, the plasma CO levels negatively correlated with PaO2 and positively correlated with RVPEP/AT. Conclusions The plasma endogenous CO levels in patients with CPHD were higher than those in normal control group. The increasing of plasma CO levels is in accodance with the increasing of the pulmonary arterial pressure and the decreasing of PaO2, which indicates that the endogenous CO participates in the regulation of pulmonary arterial pressure and plays an important role in CPHD.