Cerebral Hemorrhage Associated with Sildenafil (Revatio) in an Infant |
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Authors: | Kazunori Samada Hirohiko Shiraishi Jun Aoyagi Mariko Y Momoi |
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Institution: | (1) Department of Pediatrics, Jichi Children’s Medical Center Tochigi, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan |
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Abstract: | A case of cerebral hemorrhage associated with sildenafil (Revatio) use in an infant is presented. Sildenafil is increasingly
used in the treatment of primary and secondary pulmonary arterial hypertension and pulmonary arteriovenous fistula. In the
reported case, sildenafil used to treat pulmonary arteriovenous fistula improved right-to-left shunting across the pulmonary
fistula but resulted in cerebral hemorrhage. Cerebral hemorrhage, a previously reported complication of sildenafil, developed
in an infant after a rapid increase in dose, to 4.7 mg/kg/day. Therefore, sildenafil doses must be increased only with care,
and cerebral hemorrhage must be considered a potential complication. |
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Keywords: | |
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