口腔颌面外科10个病种手术预防性使用抗菌药物情况调查

目的：分析口腔颌面外科手术预防性使用抗菌药物情况，为口腔颌面外科手术预防性使用抗菌药物提供依据。方法：采用回顾性调查方法对北京大学口腔医院2011年1月至2013年8月期间口腔颌面外科择期手术预防性使用抗菌药物的情况及影响因素进行统计分析。结果：调查的4 331份病例中预防性抗菌药物的使用率分别是98.9%、61.8%、24.6%。随着抗菌药物使用率的下降，手术部位的感染率并没有明显增长，经Fisher精确检验差异无统计学意义(P>0.05)，手术预防性使用抗菌药物与未用抗菌药物的病例相比，术后发生手术部位感染（surgical site infections，SSI）的比例差异无统计学意义(P>0.05)。结论：手术预防性使用抗菌药物受政策干预的影响较大，随着抗菌药物使用率的下降，SSI并没有明显上升。

An investigation analysis of prophylactic application of antibiotics in ten types of oral and maxillofacial surgery

Objective:To evaluate the prophylactic application of antibiotics in oral and maxillofacial surgery and to provide a scientific basis for its reasonable use .Methods: The use of prophylactic antibiotics in the oral and maxillofacial surgery was conducted in our hospital from January 2011 to August 2013 based on a retrospective survey , and the conditions and affecting factors were analyzed .Results:The utilization rates of prophylactic antibiotics were respectively 98.9%, 61.8%, and 24.6%, showing a downward trend .But the infection rate of surgical site did not significantly increase , and by Fisher ’ s exact test, the difference was not significant (P>0.05).Surgical site infections (SSI) rates did not rise between using and not using prophylactic antibiotics ( P>0 .05 ) .Conclusion: The use of prophylactic antibiotics is greatly influenced by the policy , and along with the decline in antibiotic usage , SSI have not increased significantly .