抑郁对急性冠脉综合征患者心率变异性的影响

目的研究急性冠脉综合征(ACS)并抑郁患者心率变异性的变化。方法将临床确诊为ACS的262例患者分为抑郁组与非抑郁组,比较两组近期心血管事件的发生率并分析抑郁与各心血管事件的关系,了解ACS并抑郁患者心率变异性的变化和抑郁与心率变异性的相关性。结果ACS并抑郁患者心绞痛、急性ST段抬高心肌梗死、急性非ST段抬高心肌梗死、心力衰竭、短阵室速、室颤、心脏性死亡的发生率分别为40.8%、11.4%、19.4%、21.4%、13.3%、9.4%和8.2%。抑郁均为各心血管事件发生的独立预测因素。ACS并抑郁患者SDNN、SDANN、SDNNIDX、RMSSD、PNN50、HF均显著低于非抑郁组,VLF、LF显著高于非抑郁组。抑郁严重度指数与心率变异性各指标相关。结论ACS并抑郁患者心率变异性发生改变且抑郁与心率变异性相关。

The study of HRV variation among the ACS patients complicated by depression

Objective To investigate primarily the HRV variation among the ACS patients complicated by depression. Methods The 262 ACS patients were divided into depression group(n=98) and non- depression group(n=164).The incidence of short-term cardiovascular events and relation between depression and them were compared. The HRV variation and correlation between depression and HRV were analysed in the ACS patients complicated by depression. Results The incidence of congina cordis,STEMI,NSTEMI,CHF,ventricular tarchycardia, ventricular fibrillation and sudden death in the near future were 40.8%,11.4%,19.4%,21.4%,13.3%,9.4% and 8.2% respectively. Depression were all the independent predictive factor of the cardiovascular events .The SDNN,SDANN,SDNN index,RMSSD,PNN50 and HF were lower and VLF,LF were higher than non- depression group in the depression group. Depression seriousness index correlated with all the HRV index. Conclusion HRV has changed and correlates with depression in the ACS patients complicated by depression.