颅内软骨瘤的临床表现、超微病理学特点及其组织发生

目的观察颅内软骨瘤的超微病理学结构,结合形态学特点讨论其组织发生的来源。方法对7例发生在中颅凹底软骨瘤的活体组织标本进行透射电子显微镜观察。结果颅内软骨瘤主要发生在颅底软骨的结合处。超微病理学检查证实肿瘤组织由异常的软骨细胞构成,组织结构紊乱,细胞形态多样,瘤细胞膜表面可见粗大突起及微绒毛。胞质丰富,内有大小不等的空泡,粗面内质网扩张,可见双核瘤细胞,间质为均质状黏液物质,瘤细胞漂浮于黏液基质中。结论颅内软骨瘤由不典型的软骨细胞组成,超微结构检查显示其来源于软骨骨膜内残留的骨祖细胞。

The Characteristics of Clinical and Ultramicropathological Intracranial Chondroma and Its Histogenesis

Objective To investigate the ultrastructure and histogenesis of intracranial chondroma. The tissue origin of the tumor was studied in combination with the morphological features. Methods 7 cases biopsy specimens of chondroma in middle cranial fossa were examined with transmission electron microscopy. Results Most of intracranial chondroma were located at the position of junctura cartilaginea of basicranial skeleton. It was difficult to make a definite diagnosis by means of neuroradiologic examination. Ultrapathology confirmed the tumor tissue consisted of untypical cartilager cells. Electron microscope observed the tissue structure disturbance of chondroma and polymorphic morphology of tumor cells as well as a lot of processes and microvillus on the cell membrane surface. The tumor cells was rich of cytoplasma and a large numbers of juncturae, rough endoplasmic reticulum expansion along with the polymorphic nucleus. There are a lot of homogeneous mucous in the matrix. Conclusion The ultrastructure characteristics support that the origin of intracranial chondroma is brephic embryonic rest of osteoprogenitor cells in the basicranial periost.