| 成人急性白血病免疫表型特征分析及意义 |
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| 引用本文： | 裴敏飞,张广森,肖乐. 成人急性白血病免疫表型特征分析及意义[J]. 中南大学学报(医学版), 2000, 25(3): 262-264 |
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| 作者姓名： | 裴敏飞 张广森 肖乐 |
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| 作者单位： | |
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| 基金项目： | 部分受湖南省自然科学基金资助!(97JJY2019) |
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| 摘 要： | 采用活细胞间接免疫荧光技术 ,使用常规 8种抗CD单抗 ,测定 12 0例成人急性白血病免疫表型。结果显示免疫分型与FAB形态学分型有较高的符合率 ,但亦存在CD抗原在淋系或髓系交叉或反向表达、甚或不表达的情况。急性粒细胞白血病 (AML)M3 型和急性淋巴细胞白血病 (ALL)L3 型以及B淋巴系和T淋巴系ALL在免疫表型上各有其特点。部分免疫表型特征对提示预后有一定意义
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| 关 键 词： | 白血病 急性病 免疫表型 |
The features and significance of immunophenotyping in adult acute leukemia |
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| PEI Minfei,ZHANG Guangsen,XIAO Le,et al Research Laboratory of Hematology,The Second Affiliated Hospital,Hunan Medical University. The features and significance of immunophenotyping in adult acute leukemia[J]. Journal of Central South University. Medical sciences, 2000, 25(3): 262-264 |
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| Authors: | PEI Minfei ZHANG Guangsen XIAO Le et al Research Laboratory of Hematology The Second Affiliated Hospital Hunan Medical University |
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| Affiliation: | Research Laboratory of Hematology, The Second Affiliated Hospital, Hunan Medical University (Changsha 410011) |
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| Abstract: | Immunophenotypic assay was determined by using indirect immunofluorescent method in 120 adult patients with acute leukemia. Eight monoclonal CD antibodies consisting of antiCD2,CD7,CD10, CD19, CD13, CD33, CD14, and antiHLADR monoclonal antibodies were applied conventionally. The results were that immunophenotyping had high corresponding rate to FAB morphology typing in diagnosing acute leukemia. Also there were some patients who had cross or inverse CD marker expression or no specific CD antigen expression. There were some immunophenotypic features in AMLM 3, ALLL 3, and BLineage and TLineage acute lymphocytic leukemia respectively. Prognostic significance was observed in the patients with specific immunophenotypes, that is acute myeloid leukemia patients with lymphoid antigen (Ly AML) and some cases with inverse immunophenotypes. [ |
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| Keywords: | leukemia acute diseases immunophenotyping |
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