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| 替加环素对临床常见菌的体外抗菌活性 | |
| 引用本文： | 许宏涛,唐曼娟,陈东科,陶凤蓉,艾效曼,胡云建,张秀珍.替加环素对临床常见菌的体外抗菌活性[J].中国临床药理学杂志,2011,27(2). |
| 作者姓名： | 许宏涛 唐曼娟 陈东科 陶凤蓉 艾效曼 胡云建 张秀珍 |
| 作者单位： | 1. 北京协和医学院研究生院,北京,100730;北京医院检验科,北京100730 2. 湘潭市中心医院检验科,湖南湘潭,411100 3. 北京医院检验科,北京,100730 |
| 摘 要： | 目的评价替加环素(四环素类抗生素)对临床常见菌的体外抗菌活性。方法应用微量肉汤稀释法,对替加环素等14种药物对近2年本院临床标本中所分离的400株菌进行MIC测定,用WHONET5.4软件进行统计。结果 MIC测定结果显示:替加环素对甲氧西林耐药葡萄球菌(MRSA)和肠球菌显示了良好的体外抗菌活性,试验中有3株万古霉素耐药肠球菌(VRE),对替加环素和利奈唑胺显示敏感;对革兰阴性菌中产ESBL的大肠埃希菌和克雷伯菌属MIC90均为1μg.mL-1,仅次于或低于美罗培南;本研究中替加环素对鲍曼不动杆菌的MIC90(2μg.mL-1)在所有检测抗菌药物中最低;对铜绿假单胞菌的MIC90值为16μg.mL-1。结论替加环素对临床常见病原菌具有良好的广谱抗菌活性,对铜绿假单胞菌抗菌活性较差。 |
| 关 键 词： | 替加环素 临床常见菌 体外抗菌 |
Antibacterial activity on the clinical isolates of tigecycline in vitro |
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| XU Hong-tao,TANG Man-juan,CHEN Dong-ke,TAO feng-rong,AI Xiao-man,HU Yun-jian,ZHANG Xiu-zhen.Antibacterial activity on the clinical isolates of tigecycline in vitro[J].The Chinese Journal of Clinical Pharmacology,2011,27(2). | |
| Authors: | XU Hong-tao TANG Man-juan CHEN Dong-ke TAO feng-rong AI Xiao-man HU Yun-jian ZHANG Xiu-zhen |
| Institution: | XU Hong-tao1,2,TANG Man-juan3,CHEN Dong-ke2,TAO feng-rong2,AI Xiao-man2,HU Yun-jian2,ZHANG Xiu-zhen2(1.Graduate School,Peking Union Medical College,Beijing 100730,China,2.Department of Laboratory Medicine,Beijing Hospital,3.Department of Laboratory Medicine,Central Hospital of Xiangtan,Xiangtan,Hunan Province,411100,China) |
| Abstract: | Objective To evaluate the in vitro activity of tigecycline on the clinical isolates.Methods The minimum inhibitory concentrations(MIC) of tigecycline against 400 clinical isolates in our hospital in the 2 years lately were determined and compared with other 14 antimicrobial agents using the broth microdilution method.Data were analyzed by Whonet 5.4 software.Results The results showed that tigecycline had highly activity to methicillin resistant Staphylococcus aureus(MRSA) and Enterococcus spp..There were 3... |
| Keywords: | tigecycline clinical isolates in vitro antimicrobial |
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