| 大鼠灌胃灵芝总三萜后血浆中灵芝酸类成分的检测 |
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| 引用本文： | 薛彬彬,郭晓宇,车庆明. 大鼠灌胃灵芝总三萜后血浆中灵芝酸类成分的检测[J]. 中国药学, 2008, 17(3): 236-240 |
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| 作者姓名： | 薛彬彬 郭晓宇 车庆明 |
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| 作者单位： | 北京大学药学院天然药物学系,北京100191 |
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| 基金项目： | 教育部长江学者和创新团队发展计划，国家自然科学基金 |
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| 摘 要： | 研究灵芝中总三萜在大鼠体内的吸收情况。大鼠灌胃给予灵芝总三萜后,利用HPLC-DAD和LC-MS方法鉴定大鼠血浆中的灵芝酸类成分。在大鼠血浆中检测到5种灵芝酸类成分,即灵芝酸C2、灵芝酸C6、灵芝酸G、灵芝酸B和灵芝酸A。大鼠口服灵芝总三萜后灵芝中的灵芝酸类成分能被大鼠吸收。
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| 关 键 词： | 灵芝 三萜 灵芝酸 LC-MS HPLC-DAD |
Determination of ganoderic acids in rat plasma after oral administration of total triterpenoids from Ganoderma lucidum |
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| Bin-Bin Xue,Xiao-Yu Guo,Qing-Ming Che. Determination of ganoderic acids in rat plasma after oral administration of total triterpenoids from Ganoderma lucidum[J]. Journal of Chinese Pharmaceutical Sciences, 2008, 17(3): 236-240 |
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| Authors: | Bin-Bin Xue Xiao-Yu Guo Qing-Ming Che |
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| Affiliation: | (Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China ) |
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| Abstract: | To investigate the absorption of total triterpenoids from Ganoderma lucidum in rats. HPLC-DAD and LC-MS methods were used to identify ganoderic acids in rat plasma after oral administration of total triterpenoids from G. lucidum by comparing their HPLC retention behaviors, UV absorption spectra, and mass spectra with authentic samples. Five ganoderic acids, ganoderic acid C2, C6, G, B and A were simultaneously detected in rat plasma. Ganoderic acids can be directly absorbed into circulation after oral administration of total triterpenoids from G. lucidum in rats. |
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| Keywords: | LC-MS HPLC-DAD Ganoderma lucidum Triterpenoids Ganoderic acids LC-MS HPLC-DAD |
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