| 颅脑损伤患者血清神经丝蛋白H磷酸化亚型含量变化及其临床意义 |
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| 引用本文： | 揭园庆,余国峰. 颅脑损伤患者血清神经丝蛋白H磷酸化亚型含量变化及其临床意义[J]. 全科医学临床与教育, 2011, 9(6): 623-625 |
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| 作者姓名： | 揭园庆 余国峰 |
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| 作者单位： | 衢州市人民医院神经外科,浙江衢州,324000 |
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| 摘 要： | 目的探讨颅脑损伤患者血清中神经丝蛋白H磷酸化亚型(pNF-H)的变化及其临床意义。方法采用酶联免疫吸附法(ELISA)检测40名健康人和113例颅脑损伤患者损伤后6h、12h、24h、3d、5d、7d的血清pNF-H和S-100B水平,分析pNF-H与格拉斯哥昏迷评分(GCS)及格拉斯哥预后评分(GOS)的关系。结果观察组各时间点血清pNF-H和血清S-100B浓度均明显高于对照组,差异均有统计学意义(t分别=2.13、2.34、2.47、2.68、2.81、3.02、2.02、2.21、2.35、2.51、2.69、2.88,P均<0.05);观察组内中、重型亚组各时间点血清pNF-H浓度均明显高于轻型亚组,差异均有统计学意义(t分别=2.02、2.14、2.21、2.34、2.41、2.54、2.32、2.43、2.57、2.63、2.75、2.89,P均<0.05);重型亚组各时间点血清pNF-H浓度均明显高于中型亚组,差异均有统计学意义(t分别=2.25、2.30、2.35、2.47、2.51、2.64,P均<0.05);颅脑损伤后24h的血清pNF-H水平与24h的GCS及6个月后GOS呈负相关(r...
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| 关 键 词： | 神经丝蛋白H磷酸化亚型 S-100B蛋白 颅脑损伤 |
Change and clinical significance of serum pNF-H in patients with traumatic brain injury |
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| JIE Yuanqing,YU Guofeng. Change and clinical significance of serum pNF-H in patients with traumatic brain injury[J]. clinical education of general practice, 2011, 9(6): 623-625 |
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| Authors: | JIE Yuanqing YU Guofeng |
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| Affiliation: | JIE Yuanqing,YU Guofeng.Neurosurgery Department,Quzhou People's Hospital,Quzhou 324000,China |
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| Abstract: | Objective To explore the changes and significance of serum pNF-H in patients with traumatic brain injury.Methods Serum pNF-H and S-100B level of 40 healthy persons and 113 patients with traumatic brain injury were detected by ELISA method,and its relationship with GCS and prognosis was analyzed.Results The pNF-H and S-100B levels of patients were higher than that of the control group at observing points(t=2.13,2.34,2.47,2.68,2.81,3.02,2.02,2.21,2.35,2.51,2.69,2.88,P<0.05);the pNF-H level of medium and heavy... |
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| Keywords: | pNF-H S-100B traumatic brain injury |
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