Stem Cells for Retinal Replacement Therapy |
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Authors: | Jeffrey H Stern Sally Temple |
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Institution: | (1) Neural Stem Cell Institute, Rensselaer, NY 12144, USA |
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Abstract: | Retinal degenerative disease has limited therapeutic options and the possibility of stem cell-mediated regenerative treatments
is being actively explored for these blinding retinal conditions. The relative accessibility of this central nervous system
tissue and the ability to visually monitor changes after transplantation make the retina and adjacent retinal pigment epithelium
prime targets for pioneering stem cell therapeutics. Prior work conducted for several decades indicated the promise of cell
transplantation for retinal disease, and new strategies that combine these established surgical approaches with stem cell-derived
donor cells is ongoing. A variety of tissue-specific and pluripotent-derived donor cells are being advanced to replace lost
or damaged retinal cells and/or to slow the disease processes by providing neuroprotective factors, with the ultimate aim
of long-term improvement in visual function. Clinical trials are in the early stages, and data on safety and efficacy are
widely anticipated. Positive outcomes from these stem cell-based clinical studies would radically change the way that blinding
disorders are approached in the clinic. |
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Keywords: | |
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