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Influence of the Doping Level on the Interactions between Poly(3,4‐ethylenedioxythiophene) and Plasmid DNA |
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| Authors: | Bruno Teixeira‐Dias David Zanuy Luis J. del Valle Francesc Estrany Elaine Armelin Carlos Alemán |
| Affiliation: | 1. Departament d'Enginyeria Química, ETSEIB, Universitat Politècnica de Catalunya, Av. Diagonal 647, 08028, Barcelona, Spain;2. Center for Research in Nano‐Engineering, Universitat Politècnica de Catalunya, Campus Sud, Edifici C', C/Pasqual i Vila s/n, Barcelona E‐08028, Spain;3. Departament d'Enginyeria Agroalimentària i Biotecnología, ESAB, Universitat Politècnica de Catalunya, Av. Canal Olímpic 15, 08860, Castelldefels, Spain;4. Unitat de Química Industrial, EUETIB, Universitat Politècnica de Catalunya, Comte d'Urgell 187, 08036, Barcelona, Spain |
| Abstract: | The influence of the doping level in the formation of specific interactions between plasmid DNA and PEDOT is investigated using experimental assays and theoretical calculations. Electrochemical methods are used to prepare polymer samples with oxidation degrees ranging from 0.14 to 1.05 positive charges per repeating unit. A combination of experimental and theoretical results are used to propose a mechanism for the formation of DNA/conducting polymer complexes, which consists of the initial stabilization of the adducts through non‐specific interactions followed by small structural re‐arrangements that allow to be established specific hydrogen bonds involving the polar groups of the conducting polymer and selected DNA bases.  |
| Keywords: | conducting polymers conjugated polymers DNA doping levels specific interactions |