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International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers |
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| Authors: | Paul Kirk MBBS Taigang He MD Lisa J. Anderson MD Michael Roughton PhD Mark A. Tanner MD Wynnie W.M. Lam MD Wing Y. Au MD Winnie C.W. Chu MD Godfrey Chan MD Renzo Galanello MD Gildo Matta MD Mark Fogel MD Alan R. Cohen MD Ru San Tan MD Kevin Chen MD Ivy Ng MD Angie Lai MD Suthat Fucharoen MD Jiraporn Laothamata MD Suporn Chuncharunee MD Sutipong Jongjirasiri MD David N. Firmin MD Gillian C. Smith MD Dudley J. Pennell MD |
| Affiliation: | 1. Imperial College and Royal Brompton Hospital, London, United Kingdom;2. Chinese University of Hong Kong, Hong Kong;3. University of Hong Kong, Hong Kong;4. Ospedale Regionale Microcitemie, Cagliari, Italy;5. Azienda Ospedaliera G.Brotzu, Cagliari, Italy;6. Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA;7. National Heart Center, Singapore;8. Singapore General Hospital, Singapore;9. KK Women and Children's Hospital, Singapore;10. Mahidol University, Bangkok, Thailand;11. Ramathibodi Hospital, Mahidol University, Bangkok, Thailand |
| Abstract: | Purpose:To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.Materials and Methods:Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.Results:Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.Conclusion:These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well‐defined and approved imaging and analysis techniques are used. J. Magn. Reson. Imaging 2010;32:315–319. © 2010 Wiley‐Liss, Inc. |
| Keywords: | thalassemia cardiac siderosis cardiomyopathy cardiovascular MR |