Impulsive‐compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy |
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| Authors: | Sean S. O'Sullivan MRCPI Atbin Djamshidian MD Zeshan Ahmed PhD Andrew H. Evans MD Andrew D. Lawrence PhD Janice L. Holton PhD Tamas Revesz PhD Andrew J. Lees FRCP |
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| Affiliation: | 1. Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom;2. Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College, London, United Kingdom;3. Second Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria;4. Department of Neurology, Royal Melbourne Hospital, Parkville, Australia;5. Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff University, United Kingdom |
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| Abstract: | There is growing awareness of impulsive‐compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack pathological confirmation of diagnoses. We present three cases of pathologically confirmed progressive supranuclear palsy who developed ICBs in association with dopamine agonist use. Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made. © 2010 Movement Disorder Society |
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| Keywords: | progressive supranuclear palsy dopamine agonists impulse control disorders |
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