Pitfalls in the differential diagnosis of renal tumor in an adolescent |
| |
| Authors: | Elvis Terci Valera MD PhD María Sol Brassesco PhD Maria Angélica Abdalla de Freitas Cortez PhD Rosane Gomes Queiroz PhD Angel Mauricio Castro‐Gamero MSc Marcus Vinicius de Castro Barros MD Yvone Avalloni Vicente MD PhD Silvio Tucci Junior MD PhD Carlos Alberto Scrideli MD PhD Luiz Gonzaga Tone MD PhD |
| |
| Affiliation: | 1. Division of Pediatric Oncology, Department of Pediatrics, University of S?o Paulo, S?o Paulo, Brazil;2. Department of Genetics, University of S?o Paulo, S?o Paulo, Brazil;3. Department of Pathology, University of S?o Paulo, S?o Paulo, Brazil;4. Division of Pediatric Surgery, Department of Surgery and Anatomy, University of S?o Paulo, S?o Paulo, Brazil;5. Division of Pediatric Urology, Department of Surgery and Anatomy, School of Medicine of Ribeir?o Preto, University of S?o Paulo, S?o Paulo, Brazil |
| |
| Abstract: | The differential diagnosis of renal tumors, particularly in adolescents, may be challenging. We describe an 11‐year‐old female with a primary intra‐renal mass. Initial differential diagnoses included primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor (DSRCT), and Wilms Tumor (WT). Extensive pathologic and molecular analysis on initial and relapsed tumor samples confirmed WT. The EWS‐WT1 and EWS‐FLI1 rearrangements, distinctive of DSRCT and PNET were negative. The differential diagnosis on monophasic blastemal WT may be complex. Primary renal DSRCT and PNET have been rarely described. Nevertheless, molecular confirmation for these rare conditions may be necessary in selected cases. Pediatr Blood Cancer 2010;54:319–321. © 2009 Wiley‐Liss, Inc. |
| |
| Keywords: | cancer genetics cytogenetics molecular genetics pathology renal tumors wilms tumor |
|
|
