1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy;2. Istituto di Chimica e Tecnologia dei Polimeri, Consiglio Nazionale delle Ricerche, Via Gaifami 18, 95126 Catania, Italy;3. Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy;4. Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy
Abstract:
Linking PEG2,000 polymers ending in 1 or 2 carboxylic groups to lipoamino acids (LAAs) gives mono‐ and homo‐disubstituted PEG‐LAA conjugates. They show an identical solubility to parent PEGs in water and organic solvents. By DSC the degree and depth of interaction of these conjugates with a biomembrane model is studied, gaining information about their future incorporation in drug‐loaded nanocarriers. The ability of PEG‐LAA conjugates to adopt an ordinate arrangement on the surface of particles and efficiently cover them is demonstrated, compared to DSPE‐PEG, by measuring the zeta potential values of negatively charged liposomes prepared in their presence.
