Decreased ventral striatal activity with impulse control disorders in Parkinson's disease |
| |
| Authors: | Hengyi Rao PhD Eugenia Mamikonyan MS John A. Detre MD Andrew D. Siderowf MD MSCE Matthew B. Stern MD Marc N. Potenza MD PhD Daniel Weintraub MD |
| |
| Affiliation: | 1. Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA;2. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA;3. Center for Functional Brain Imaging and Center for Studies of Psychological Application, South China Normal University, Guangzhou, China;4. Potential conflict of interest: The authors report no conflicts of interest.;5. Parkinson's Disease Research, Education and Clinical Center, and Mental Illness Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, Pennsylvania, USA;6. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA;7. Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA |
| |
| Abstract: | A range of impulse control disorders (ICDs) are reported to occur in Parkinson's disease (PD). However, alterations in brain activity at rest and during risk taking occurring with ICDs in PD are not well understood. We used both arterial spin labeling perfusion functional magnetic resonance imaging (fMRI) to directly quantify resting cerebral blood flow (CBF) and blood oxygenation level dependent (BOLD) fMRI to measure neural responses to risk taking during performance on the Balloon Analogue Risk Task (BART). Eighteen PD patients, either with a diagnosis of one or more ICDs (N = 9) or no lifetime ICD history (N = 9), participated. BOLD fMRI data demonstrated that PD patients without an ICD activate the mesocorticolimbic pathway during risk taking. Compared with non‐ICD patients, ICD patients demonstrated significantly diminished BOLD activity in the right ventral striatum during risk taking and significantly reduced resting CBF in the right ventral striatum. ICDs in PD are associated with reduced right ventral striatal activity at rest and diminished striatal activation during risk taking, suggesting that a common neural mechanism may underlie ICDs in individuals with PD and those without PD. Thus, treatments for ICDs in non‐PD patients warrant consideration in PD patients with ICDs. © 2010 Movement Disorder Society |
| |
| Keywords: | functional magnetic resonance imaging Parkinson's disease impulse control disorder |
|
|
