Plasma α‐synuclein in patients with Parkinson's disease with and without treatment |
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| Authors: | Raquel Duran PhD Francisco J Barrero MD Blas Morales MD Juan D Luna PhD Manuel Ramirez MD Francisco Vives PhD MD |
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| Institution: | 1. Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada, Spain;2. Movement Disorder Unit, Department of Neurology, San Cecilio University Hospital, Granada, Spain;3. Department of Statistics, Faculty of Medicine, University of Granada, Spain;4. Unit of Physiology, Department of Health Sciences, University of Jaén, Jaén, Spain |
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| Abstract: | Alpha‐synuclein (α‐syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). α‐Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma α‐syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma α‐syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, α‐syn was elevated early in the development of PD and specific PD treatment did not change plasma α‐syn levels. © 2010 Movement Disorder Society |
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| Keywords: | Parkinson's disease α ‐synuclein pathogenesis Parkinson's disease treatment plasma |
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