A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection |
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| Authors: | Horng‐Ren Yang MD Ching‐Chuan Hsieh MD Lianfu Wang MD John J Fung MD PhD Lina Lu MD Shiguang Qian MD |
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| Institution: | 1. Department of General Surgery, Cleveland Clinic, Cleveland, OH;2. Department of Surgery, China Medical University Hospital, Taiwan;3. Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH |
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| Abstract: | Hepatic stellate cells (HSCs) have demonstrated a strong T‐cell inhibitory activity. In a mouse islet transplantation model, cotransplanted HSCs can protect islet allografts from rejection. The involved mechanism is not fully understood. We showed in this study that expression of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), an important apoptosis‐inducing ligand, on HSCs was crucial in protection of islet allografts, since HSCs derived from TRAIL knockout mice demonstrated less inhibitory activity towards T‐cell proliferative responses, and substantially lost their capacity in protecting cotransplanted islet allografts from rejection, suggesting that TRAIL‐mediated T cell apoptotic death is important in HSC‐delivered immune regulation activity. © 2009 Wiley‐Liss, Inc. Microsurgery 2010. |
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