Fungal infections in solid organ transplantation: An update on diagnosis and treatment |
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Authors: | Vincent Kabir Johan Maertens Dirk Kuypers |
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Affiliation: | 1. KU Leuven, Leuven, Herestraat 49, 3000 Leuven, Belgium;2. KU Leuven, Laboratory of Clinical Bacteriology and Mycology, Herestraat 49, 3000 Leuven, Belgium;3. KU Leuven, Laboratory of Nephrology, Herestraat 49, 3000 Leuven, Belgium;4. Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium |
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Abstract: | Invasive fungal infections constitute an important cause of morbidity and mortality in solid organ transplantation recipients. Since solid organ transplantation is an effective therapy for many patients with end-stage organ failure, prevention and treatment of fungal infections are of vital importance. Diagnosis and management of these infections, however, remain difficult due to the variety of clinical symptoms in addition to the lack of accurate diagnostic methods. The use of fungal biomarkers can lead to an increased diagnostic accuracy, resulting in improved clinical outcomes. The evidence for optimal prophylactic approaches remains inconclusive, which results in considerable variation in the administration of prophylaxis. The implementation of a standard protocol for prophylaxis remains difficult as previous treatment regimens, which can alter the distribution of different pathogens, affect the outcome of antifungal susceptibility testing. Furthermore, the increasing use of antifungals also contributes to incremental costs and the risk of development of drug resistance. This review will highlight risk factors, clinical manifestations and timing of fungal infections and will focus predominately on the current evidence for diagnosis and management of fungal infections. |
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Keywords: | Solid organ transplantation Fungal infections AP aerosolized pentamidine BAL bronchoalveolar lavage BDG (1,3,)-β-d-Glucan BID twice daily EORTC European Organisation for Research and Treatment of Cancer G6PD glucose-6-phosphatase dehydrogenase GM galactomannan GMS Grocott methenamine silver HR hazard ratio IA invasive aspergillosis IDSA Infectious disease society of America IFI invasive fungal infection IF/Mab immunofluorescent staining with monoclonal antibodies L-AmB lipid formulation of amphotericin B LTx lung transplantation MHb methemoglobinemia MSG Infectious Diseases Mycoses Study Group PJP pneumocystis jiroveci pneumonia PPV positive predictive value QD once daily SOT solid organ transplantation TDM therapeutic drug monitoring TMP-SMX trimethoprim–sulphamethoxazole |
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