Onset of dyskinesia with adjunct ropinirole prolonged‐release or additional levodopa in early Parkinson's disease |
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| Authors: | Ray L Watts MD Kelly E Lyons PhD Rajesh Pahwa MD Kapil Sethi MD Matthew Stern MD Robert A Hauser MD Warren Olanow MD Alex M Gray PhD Bryan Adams PhD Nancy L Earl MD On Behalf of the Study Investigators |
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| Institution: | 1. Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA;2. Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA;3. Department of Neurology, Medical College of Georgia, Augusta, Georgia, USA;4. Department of Neurology, University of Pennsylvania/Pennsylvania Hospital, Philadelphia, Pennsylvania, USA;5. Department of Neurology, University of South Florida, Tampa, Florida, USA;6. Department of Neurology, Mount Sinai Medical Center, New York, New York, USA;7. Division of Neurosciences, US Clinical, GlaxoSmithKline, Research Triangle Park, North Carolina, USA;8. Deceased |
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| Abstract: | Levodopa‐induced dyskinesia can result in significant functional disability and reduced quality of life in patients with Parkinson's disease (PD). The goal of this study was to determine if the addition of once‐daily ropinirole 24‐hour prolonged‐release (n = 104) in PD patients not optimally controlled with levodopa after up to 3 years of therapy with less than 600 mg/d delays the onset of dyskinesia compared with increasing doses of levodopa (n = 104). During the study, 3% of the ropinirole prolonged‐release group (mean dose 10 mg/d) and 17% of the levodopa group (mean additional dose 284 mg/d) developed dyskinesia (P < 0.001). There were no significant differences in change in Unified Parkinson's Disease Rating Scale activities of daily living or motor scores, suggesting comparable efficacy between the two treatments. Adverse events were comparable in the two groups with nausea, dizziness, insomnia, back pain, arthralgia, somnolence, fatigue, and pain most commonly reported. Ropinirole prolonged‐release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa. © 2010 Movement Disorder Society |
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| Keywords: | dyskinesia Parkinson's disease ropinirole prolonged‐release levodopa |
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