A new paradigm for high‐sensitivity 19F magnetic resonance imaging of perfluorooctylbromide |
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| Authors: | Céline Giraudeau Julien Flament Benjamin Marty Fawzi Boumezbeur Sébastien Mériaux Caroline Robic Marc Port Nicolas Tsapis Elias Fattal Eric Giacomini Franck Lethimonnier Denis Le Bihan Julien Valette |
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| Affiliation: | 1. Neurospin, I2BM, Commissariat à l'Energie Atomique, Gif‐sur‐Yvette, France;2. Guerbet, Research Division, Aulnay‐sous‐Bois, France;3. Université Paris Sud, UMR CNRS 8612, Faculté de Pharmacie, Chatenay‐Malabry, France |
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| Abstract: | In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high‐sensitivity fluorine MRI strategy. It is shown that the harmful effects of J‐coupling can be eliminated by carefully choosing the bandwidth of the 180° pulses in a spin‐echo sequence. The T2 of the CF3 resonance of the molecule is measured using a multispin‐echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin‐echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin‐echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles. Magn Reson Med 63:1119–1124, 2010. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | PFOB 19F spin echo sensitivity J‐coupling T2 |
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